Cells orchestrate a plethora of processes that are obligatory for an organism’s sustenance. Evolutionary stable strategy of every life form dictates specific homeostatic integrity of several such cellular processes. Deviation from this homeostasis is often represented as anomalies that promote disease etiologies. At CDHL, we look into the variegated facets of cell and its constituents in diverse metabolic processes, stress-mediated damages, along with the holistic contribution of cellular dyshomeostasis in various pathological conditions. Our research interests dwell in this diversified paraphernalia of cellular dyshomeostasis to comprehend the functional demeanors of conglomerations of different cellular pathways in varied pathological conditions, ranging from degenerative diseases and aging to aneuploidy and cancer.
- Chromosomal instability-associated anomalies in evading cell cycle check-points in cancer.
- Mitochondria-extramitochondrial cross-talks in human cellular aging.
- Mitochondrial stress in cardiovascular diseases, particularly in association with endothelial signaling and inflammatory responses.
- Designing novel anticancer drugs against breast adenocarcinoma.
Collaborations: Multipronged approach to tackle the complexities of cancer therapy. This is in continuation of our work on evasion of anti-growth signaling in the Halifax Project (2012-2015; Getting To Know Cancer, Truro, Nova Scotia, Canada), which was a highly prestigious global consortium of 350 scientists from 31 countries. Dr. Gunjan Guha & Dr. Dipita Bhakta-Guha were two out of three scientists from India who participated in the project.
Research in CDHL is funded by: